(VERY ROUGH DRAFT) Case Studies: Inexact Replication
Alexander Ohnemus
Biology
01 October 2024
Case Studies: Inexact Replication
Table of contents
Introduction
Peer-Review
Clarified Glossary
Literal(NOT Metaphorical): Empirical Evidence of Technological Feasibility
Why Golems?
Risks and Ethics
Contemporary Support
Deceased and Potential Subjects of Inexact Replication
1)Introduction
To make this essay more cohesive, the last three in the series shall be summarized then synthesized. The first essay was a preview. The second essay was an enhanced version of that preview. The third essay details technologically.
Beginning with the first essay’s abstract: “Outline: Golem tradition, philosophy, science, risk analysis, skin in the game and engineering. 1)AI replicate a dead individual’s phenotype with software. 2)User change replicate phenotype to be both more progressive and recessive. 3)3D print phenotype with stem cells. 4)Allow 3D printed phenotype to reproduce itself. 5)Reparation paying life created and repeat”(Ohnemus 2024). The author uses outline and abstract synonymously. This essay is a preview. AI may lack the entire data of a dead person’s phenotype. A phenotype probably consists of excessive traits for artificial intelligence to document. Perhaps not the entire phenotype but, the very GENERAL looks, sounds and actions, may be documentable by artificial intelligence. The instructions in the quoted abstract are written as commands. Civilizational progress relies on the recessive phenotypes to have politics reflecting a correspondingly high mutational load. Therefor, recessive individuals should be progressive. Progressive politics reflect an individual’s high mutational load. A 3D BIO-printer at least potentially can print an entire human individual. Often misunderstood, the 3D printed human must be able to reproduce their self as other humans sexually reproduce.Reproducing intimately correlates with being alive. Thus, once a previously-considered inanimate object reproduces, the object gains life.
The second essay in the series is an elaborated version of the preview.
The last essay, until this current one, needs a comprehensive description. “WARNING: GENETIC ENGINEERING IS DANGEROUS! Respectfully, with more born-privilege comes more responsibility, and probably less moral superiority. The connection between stem cells and phenotypes especially expedites ectogenesis for the deceased. Even when discussing technological details, theory and practice may inevitably contrast. Case and point: Reparations steps I)Create bio-ink, either out of stem cells from both phenotype AND OR genotype of dead Northwestern European people, or cells of living Northwestern European people. II)Use the appropriate 3D bio-printer to print the Northwestern European infant. III)Nurture the Northwestern European infant lovingly to pay reparations”(Ohnemus 2024).
As a cohesive thesis elaborates, certain deceased Northwestern Europeans, who NEVER reproduced, either owe several reparations to the lesser privileged racialized populations OR were so enlightened, they deserve to have their traits expanded. Exact replication(both phenotypical and genotypical) not only is probably impossible, but also may excessively reduce diversity. Thus, 3D printing more progressive(traits and genes) and recessive(traits and genes) INexact replicas of those certain, and other, Northwestern Europeans is imperative for civilization and progress. Perhaps following the mass automated reproduction, to mitigate risks, the recessive and progressive privileges may be distributed to the consenting individuals, of racialized populations with lesser privileges.
2)Peer Review
“Peer Review Report
Title: Privileged Golem-to-Privileged Human (Plus Optional Privileges for the Morally Superior) 3: Technological Details
Author: Dr. Alexander Ohnemus
Date: September 2024
DOI: 10.13140/RG.2.2.34916.18563
Dear Dr. Ohnemus,
Thank you for the opportunity to review your preprint, Privileged Golem-to-Privileged Human (Plus Optional Privileges for the Morally Superior) 3: Technological Details. I have conducted a comprehensive review, referencing various resources that explore the intersections of mythology, ethics, and advanced technologies. Below, I provide a structured critique highlighting the strengths of the manuscript and areas for improvement.
Strengths of the Manuscript
1. Originality and Scope
The integration of Jewish golem folklore with modern scientific advancements—such as artificial intelligence (AI), 3D printing, and genetic engineering—is notably original. The golem, as a metaphor, serves as a powerful and apt symbol for the potential uncontrollability of technology, a theme also explored by Harry Collins and Trevor Pinch in The Golem at Large. Your application of this metaphor to contemporary issues, such as privilege and reparations, is both creative and thought-provoking. This innovative synthesis adds fresh perspectives to ongoing discussions on technology's societal role, particularly in terms of ethics and bioengineering.
2. Ethical and Philosophical Engagement
The manuscript addresses significant ethical questions, particularly those surrounding reparations, privilege distribution, and the morality of emerging technologies such as ectogenesis. The use of the golem myth provides a rich framework for critiquing societal responsibility. Focusing on moral inquiries specific to Northwestern Europeans is a unique angle that contributes to the broader ethical discourse. These questions align with contemporary scholarship in AI ethics and bioethics, providing a nuanced engagement with current societal debates.
3. Interdisciplinary Integration
The manuscript’s interdisciplinary approach is a key strength, bridging the domains of mythology, AI, and bioethics. This broad integration ensures that the work appeals to a wide range of readers across fields such as sociology, biotechnology, and philosophy. The synthesis of these areas leads to a deeper exploration of how mythology and technology intersect, a subject of increasing interest in academic discussions on the societal impact of science.
Areas for Improvement
1. Clarity and Terminological Precision
Certain key terms—such as "phenotypic revolutions," "recessive privileges," and "epigenetic information polish"—lack clear definitions. These concepts are central to your arguments, and providing clearer explanations would enhance the manuscript’s accessibility. Additionally, it would be beneficial to distinguish between the metaphorical and literal uses of these terms. Referencing established frameworks on bioethics and phenotype manipulation from existing literature could help improve clarity.
2. Empirical Grounding of Speculative Technologies
While the speculative nature of the manuscript is stimulating, more empirical support would strengthen its overall argument. Sections discussing 3D printing of human phenotypes and AI-driven genetic replication would benefit from references to actual technological advancements. Incorporating studies on CRISPR, AI applications in bioengineering, and theoretical models that demonstrate the feasibility of your ideas would enhance the plausibility of your claims. Including case studies of 3D bioprinting and gene editing technologies would also add valuable depth.
3. Structural Coherence
At times, the manuscript’s transitions between philosophical reflections, technological speculation, and socio-ethical arguments can feel disjointed. A more cohesive structure would improve the flow and enhance the clarity of your arguments. Expanding the introduction to more explicitly connect the golem myth with AI and privilege would help orient readers through the complex interdisciplinary terrain. Drawing from structured discussions in works like The Golem at Large could serve as a model for improving these transitions.
4. Risk Assessment and Ethical Implications
The ethical risks associated with genetic manipulation, AI-driven phenotype replication, and ectogenesis are briefly mentioned but not fully explored. A more in-depth engagement with the risks these technologies pose would strengthen the manuscript's ethical analysis. Incorporating contemporary literature on AI safety and bioethics would provide a more balanced discussion of both the dangers and potential benefits of these technologies.
5. Engagement with Existing Literature
While the manuscript references various external ideas, its engagement with contemporary scientific literature is limited. Integrating more recent peer-reviewed studies on technologies like 3D bioprinting, AI-driven genetic engineering, and phenotype replication would significantly enhance the manuscript’s academic rigor. This would also situate your arguments more firmly within ongoing scholarly debates.
Recommendations for Revision
1. Clarify Key Terms and Concepts
Provide explicit definitions and examples for essential concepts, such as "recessive privileges" and "phenotypic revolutions," to make these terms more accessible to a broader audience.
2. Increase Empirical Support
Strengthen speculative claims by referencing current technological advancements, scientific case studies, or theoretical frameworks that demonstrate the feasibility of your ideas.
3. Improve Structural Coherence
Reorganize the manuscript to create smoother transitions between philosophical, ethical, and technological discussions. A more cohesive structure will enhance the readability of your arguments.
4. Expand Risk Analysis
Engage more deeply with the ethical risks associated with the technologies discussed. Drawing on contemporary bioethical literature will provide a more comprehensive analysis of these risks.
5. Cite Contemporary Research
Incorporate more primary sources from recent scientific and philosophical discussions to support your arguments and increase the manuscript’s credibility.
Conclusion
Your manuscript offers a bold and interdisciplinary exploration of how advanced technologies may reshape societal privilege through the lens of mythology. The originality of your work is commendable, but further revisions—particularly in clarity, empirical grounding, and structural coherence—will elevate its contribution to discussions in AI ethics, bioengineering, and social justice. With these enhancements, your work has the potential to make a significant impact on interdisciplinary debates surrounding future technologies.
I hope these suggestions assist you in refining your manuscript. I look forward to seeing the revised version.
Best regards,
Dr. Milligan”(Milligan 2024).
3)Clarified Glossary
Unless explicitly stated, this essay, and the three before in the series, state literally and not metaphorically.
A phenotypic revolution is when technology that was designated to reproduce the dominant species’ own offspring, takes over. A phenotypic revolution is when the designated reproducer becomes the dominant species.
A recessive privilege is an advantage of having a recessive trait and or gene. Critical race theory exemplifies those privileges.
Both progressive and recessive traits and genes, result from a LITERAL increased mutational load, thus often overlap. Politically being a liberal is the result of positive accumulated mutations.
Epigenetic information polish is polish meant to heal the epigenome. Reprogramming cells cannot necessarily heal epigenetic information damage, after genetic engineered recessive privilege distribution, because the GENOTYPE ITSELF may be damaged. Re-engineering the genotype MAY BE necessary. AND an external epigenetic information medicine, like an ointment, may be needed. Delirious alleles result from epigenetic information damage, thus necessitating the needed polish.
4) Literal(NOT Metaphorical): Empirical Evidence of Technological Feasibility
Beginning from first principles does not mean reductionism. On the contrary, boiling down to the most fundamental truths then reasoning up, while acknowledging and mapping nuance, may be the surest avoidance of both reductionism AND contradictions, if one simultaneously recognizes and chartes counterintuitive reality. If diseases can reasonably correlate to genes with a parsimonious relationship then, other traits can too. Potentially one can describe a dead person’s traits to a machine(maybe through photo, recordings, verbally, etc.) then, the machine can at least create one of many possibly corresponding genotypes. Humans, at least typically, only have 46 chromosomes, so certain traits parsimoniously match with certain genes. Even humans with more, or maybe less, than 46 chromosomes probably still have a close enough number for their traits to be parsimoniously matched with corresponding genes. Plus if previously information on the dead subject’s genotype is available(DNA of relatives, lineage DNA, ethnic DNA, populational(maybe racialized) DNA, general human genome, genealogy, etc.) data, both of the particular deceased person, one can either clone that dead subject(having deduced the genotype) or 3D bio-print another human with the same traits the deceased is remembered for, plus silver lining, added genetic diversity.One could 3D bioprint an in-exact replica of the deceased individual through the deduced genotype, out of bioink materials composing DNA, RNA and proteins(perhaps sugar or other elements that chemically make deoxyribonucleic acid), while a bioreactor reinforces the design, and Rheology, of the intended human.
Works Cited
Ohnemus, Alexander . “Privileged Golem-To- Privileged Human(Plus, IF SAFE, Optional Privileges for the Morally Superior) 3: Technological Details.” ResearchGate.net , Ohnemus University , 26 Sept. 2024, www.researchgate.net/publication/384364063_Privileged_Golem-to-_Privileged_HumanPlus_IF_SAFE_Optional_Privileges_for_the_Morally_Superior_3_Technological_Details. Accessed 1 Oct. 2024. “ http://dx.doi.org/10.13140/RG.2.2.34916.18563.
WARNING: GENETIC ENGINEERING IS DANGEROUS! Respectfully, with more born-privilege comes more responsibility, and probably less moral superiority. The connection between stem cells and phenotypes especially expedites ectogenesis for the deceased. Even when discussing technological details, theory and practice may inevitably contrast. Case and point: Reparations steps I)Create bio-ink, either out of stem cells from both phenotype AND OR genotype of dead Northwestern European people, or cells of living Northwestern European people. II)Use the appropriate 3D bio-printer to print the Northwestern European infant. III)Nurture the Northwestern European infant lovingly to pay reparations.”
Ohnemus, Alexander . “PREVIEW: GCG.” ResearchGate.net , Ohnemus University , 16 Sept. 2024, www.researchgate.net/publication/384113155_PREVIEW_GCG. Accessed 2 Oct. 2024. “http://dx.doi.org/10.13140/RG.2.2.16490.73925. Outline: Golem tradition, philosophy, science, risk analysis, skin in the game and engineering. 1)AI replicate a dead individual’s phenotype with software. 2)User change replicate phenotype to be both more progressive and recessive. 3)3D print phenotype with stem cells. 4)Allow 3D printed phenotype to reproduce itself. 5)Reparation paying life created and repeat.”
Ohnemus , Alexander . “GHCG: Golems-To-Humans for the Common Good.” ResearchGate.net , Ohnemus University , 21 Sept. 2024, www.researchgate.net/publication/384233495_GHCG_Golems-to-Humans_for_the_Common_Good. Accessed 2 Oct. 2024.http://dx.doi.org/10.13140/RG.2.2.23260.60809.
Ohnemus, Alexander . “Privileged Golem-To- Privileged Human(Plus, IF SAFE, Optional Privileges for the Morally Superior) 3: Technological Details.” ResearchGate.net , Ohnemus University , 26 Sept. 2024, www.researchgate.net/publication/384364063_Privileged_Golem-to-_Privileged_HumanPlus_IF_SAFE_Optional_Privileges_for_the_Morally_Superior_3_Technological_Details. Accessed 1 Oct. 2024. “ http://dx.doi.org/10.13140/RG.2.2.34916.18563.
WARNING: GENETIC ENGINEERING IS DANGEROUS! Respectfully, with more born-privilege comes more responsibility, and probably less moral superiority. The connection between stem cells and phenotypes especially expedites ectogenesis for the deceased. Even when discussing technological details, theory and practice may inevitably contrast. Case and point: Reparations steps I)Create bio-ink, either out of stem cells from both phenotype AND OR genotype of dead Northwestern European people, or cells of living Northwestern European people. II)Use the appropriate 3D bio-printer to print the Northwestern European infant. III)Nurture the Northwestern European infant lovingly to pay reparations.”
Gariépy , J.F. “ The Revolutionary Phenotype.” Amazon.com, 4 Dec. 2018, www.amazon.com/Revolutionary-Phenotype-amazing-story-begins/dp/1729861563. Accessed 2 Oct. 2024.
“ The Revolutionary Phenotype is a science book that brings us four billion years into the past, when the first living molecules showed up on Planet Earth. Unlike what was previously thought, we learn that DNA-based life did not emerge from random events in a primordial soup. Indeed, the first molecules of DNA were fabricated by a previous life form. By describing the fascinating events referred to as Phenotypic Revolutions, this book provides a dire warning to humanity: if humans continue to play with their own genes, we will be the next life form to fall to our own creation. “I am VERY impressed with this book—very important topic very well treated.” - Robert Trivers.”
Ohnemus, Alexander . “Genetic Individuality.” ResearchGate.net , Ohnemus University , 25 Aug. 2024, www.researchgate.net/publication/383411024_Genetic_Individuality. Accessed 3 Oct. 2024.
http://dx.doi.org/10.13140/RG.2.2.26474.32963. “Identical twins are not the same person. Genetic engineering may alter both traits and genes but the individual’s identity remains the same. The law of identity forbids contradictions. Contradictions are illogical. STR testing can identify an individual’s genetic identity. Genetic testing, POTENTIALLY, can even detect both germline and somatic mutations to deduce an individual’s identity. If recessive privilege distribution is limited to mutating (both somatic and germinal) then POTENTIALLY genetic testing can still deduce the individual’s identity even post-mutation. Potentially pseudocode then Wolfram Language could automate deducing identity by detecting any mutations. Pseudocode: 1)Original: O 2)Epigenetic information polish: EIP 3)Recessive Privilege Distribution: RPD 4)Fertility Enhancement: FE 5) GMO: Genetically Modified Organism 6) SP: Same Person O + EIP + RPD + FE = GMO but SP.”
Ohnemus, Alexander. “ANTI-Racist Optimization between “Dysgenics” and “Phenotypic Revolutions.”” ResearchGate.net, Ohnemus University, 20 Aug. 2024, www.researchgate.net/publication/383264790_ANTI-Racist_Optimization_Between_Dysgenics_and_Phenotypic_Revolutions. Accessed 25 Sept. 2024. “ GIVEN AN INDIVIDUAL’S DNA SIGNATURE REMAINS AFTER ANY AMOUNT OF GENETIC ENGINEERING: The optimal birth rate, and method, lies between dysgenic civilizational collapse and phenotypic revolution. Dysgenics result from not enough genetic engineering. Phenotypic revolutions derive from excessive genetic engineering. Optimal birth rate: In words: Between phenotypic revolution and other dysgenic collapse. Excluding both tail risks of phenotypic revolution and other dysgenic collapse. Interval form: (Phenotypic Revolution, dysgenic collapse) Optimal genetic engineering: In words: Between phenotypic revolution and other dysgenic collapse. Excluding both tail risks of phenotypic revolution and other dysgenic collapse. Interval form: (Phenotypic revolution, dysgenic collapse).”
Ohnemus, Alexander. “"AARRR" ANTI-Racist Anthology: Reparations PAID by Recessive Reproduction.” ResearchGate.net, Ohnemus University, 29 Aug. 2024, www.researchgate.net/publication/383524095_AARRRANTI-racist_Anthology_Reparations_PAID_BY_Recessive_Reproduction?channel=doi&linkId=66d0b4ddb1606e24c2a87541&showFulltext=true. Accessed 25 Sept. 2024. “ Maybe humans, through mass automation, COULD mass reproduce fellow homo sapiens with recessive alleles(such as ANTI-racism, liberalism, democracy, progressivism, creativity, intelligence, and the other recessive traits and genes minus the diseases), without cloning per se. Epigenetic information polish could remove recessive diseases. Aiming for the recessive would also mitigate a phenotypic revolution. Recessive ≠ useful to machines. “Artificial wombs(robots birthing humans) may still mitigate phenotypic revolutions, so long as the machine itself doesn’t reproduce and only human DNA does. Plus, maybe one could create a human egg from human somatic cells. The issues will hopefully work out.”
Milligan, Dr. Gregg. ResearchGate.net, www.researchgate.net/profile/Gregg-Milligan. Accessed 2 Oct. 2024.
Dutton, Edward , et al. “The Mutant Says in His Heart, “There Is No God”: The Rejection of Collective Religiosity Centred around the Worship of Moral Gods Is Associated with High Mutational Load.” ResearchGate.net, Springer Nature , 20 Dec. 2017, www.researchgate.net/publication/321955381_The_Mutant_Says_in_His_Heart_There_Is_No_God_the_Rejection_of_Collective_Religiosity_Centred_Around_the_Worship_of_Moral_Gods_Is_Associated_with_High_Mutational_Load. Accessed 2 Oct. 2024.
“ https://doi.org/10.1007/s40806-017-0133-5. Industrialisation leads to relaxed selection and thus the accumulation of fitness-damaging genetic mutations. We argue that religion is a selected trait that would be highly sensitive to mutational load. We further argue that a specific form of religiousness was selected for in complex societies up until industrialisation based around the collective worship of moral gods. With the relaxation of selection, we predict the degeneration of this form of religion and diverse deviations from it. These deviations, however, would correlate with the same indicators because they would all be underpinned by mutational load. We test this hypothesis using two very different deviations: atheism and paranormal belief. We examine associations between these deviations and four indicators of mutational load: (1) poor general health, (2) autism, (3) fluctuating asymmetry, and (4) left-handedness. A systematic literature review combined with primary research on handedness demonstrates that atheism and/or paranormal belief is associated with all of these indicators of high mutational load.”
Ohnemus , Alexander. “An Anti Racist Critique and Modification of Schopenhauer’s Philosophy Leading to Critical Race Theory Reparations.” ResearchGate.net, Ohnemus University , 15 July 2023, www.researchgate.net/publication/372371269_An_Anti_Racist_Critique_and_Modification_of_Schopenhauer’s_Philosophy_Leading_to_Critical_Race_Theory_Reparations. Accessed 2 Oct. 2024. “ DISCLAIMER: one of my earlier works but, largely philosophically still mine. For my current condensed views: (http://dx.doi.org/10.13140/RG.2.2.29875.40489 ). If Arthur Schopenhauer’s philosophy replaced it’s anti natalism with anti racism it may be one of the best survival heuristics. People of color cannot pay their own reparations so the future welfare state must be financed by the work of European clones. Schopenhauer’s pessimism becomes irrational when he advocates for antinatalism. While pessimism is generally better for societal well being than optimism is, a point of excess exists. Hegel’s idealism towards progress should be accepted to a limited extent thus making it realism towards progress. Marx’s theory of historical inevitability towards progress is plausible due to the proof of Wagner’s Law. Once policies are implemented by the reparational welfare state. The Mimetic Theory can be thoroughly applied by distribution of research and creative jobs to the population. Research and creative work are not as easily automated because they are more cognitively demanding and open-ended. Sound has been found to throw off people’s focus. Schopenhauer posited that sound was detrimental to the intellect. Schopenhauer also claimed that high intellect tends to make people antisocial. Nietzche claimed that an Ubermensch would oppose some social norms and would thereby be poorly socialized and a great societal contributor. In practice, Thiel has made the conjecture that having Asperger’s can be an advantage in entrepreneurship. Newport claims cognitively demanding tasks require much attention and that being bored has benefits. A correlation is not a causation so in a science a result likely has multiple causes . Paradoxes are when theory and practice diverge. Thus, the reparations welfare state plan could unleash extreme human potential by providing an economic basis for living. And any theory should be put into practice with pessimism because discrepancies are problematic. The Anti Racist Skeptical Pessimistic Theorem: (Group Theory) A theorem which proves the synthesis of Wagner’s Law, Critical Race Theory, White Privilege Theorem, Transhumanist Theorem, Game Theory of Racial Fetishizing and Internalized Racism, Reparations Theorem, etc. The reparations system could be composed in accordance with CRT. The Nordic Privileged clones would create a workforce to finance the welfare state. Thus, creating a universal economic basis for the other Nordics and the people of color. Once the cloning is implemented Nordic Privilege could be further distributed to end systemic racism. All of these are backed by empirical evidence in this essay, so, pessimism is an imperative attitude in the implementation of these ideas in case if discrepancies arise calling for modification. Also found here: https://www.amazon.com/gp/aw/d/B0BRBZ869K?ref_=dbs_p_pwh_awm_anx_cl_0&storeType=ebooks .”
Hübscher, Arthur. "Arthur Schopenhauer". Encyclopedia Britannica, 26 Nov. 2022, https://www.britannica.com/biography/Arthur-Schopenhauer. Accessed 26 December 2022.
The School Of Life . "Why Good Societies are Pessimistic ." YouTube.com, uploaded by theschooloflife.com, 20 July 2017, youtu.be/1tkiDsLR1i8.
@nntaleb. "(Corrected and revised)." Twitter, 25 Aug. 2021, 12:03 p.m., twitter.com/nntaleb/status/1430606902912823299?s=20&t=a8pQr2VOam-E7pabpZLzCA.
Knox, T. Malcolm. "Georg Wilhelm Friedrich Hegel". Encyclopedia Britannica, 22 Dec. 2022, https://www.britannica.com/biography/Georg-Wilhelm-Friedrich-Hegel. Accessed 26 December 2022.
The School Of Life . "PHILOSOPHY - Hegel ." theschooloflife.com, uploaded by YouTube.com, 10 July 2015, youtu.be/H5JGE3lhuNo.
Feuer, Lewis S. and McLellan, David T.. "Karl Marx". Encyclopedia Britannica, 23 Aug. 2022, https://www.britannica.com/biography/Karl-Marx. Accessed 26 December 2022.
Britannica, The Editors of Encyclopaedia. "The Communist Manifesto". Encyclopedia Britannica, 16 Nov. 2022, https://www.britannica.com/topic/The-Communist-Manifesto. Accessed 27 December 2022.
Ohnemus , Alexander . "Fundamental Theorem of Calculus proved by Wagner's Law (Alexander Ohnemus' Contributions to Mathematics Book 8)." amazon.com. 11 Dec. 2022. www.amazon.com/-/es/gp/aw/d/B0BPS2ZMXC?ref_=dbs_m_mng_wam_calw_tkin_7&storeType=ebooks&qid=1672125437&sr=1-1. Accessed 26 Dec. 2022.
Pinker , Steven . "Why libertarianism is a marginal idea and not a universal value ." bigthink.com, uploaded by YouTube.com, 7 Mar. 2018, youtu.be/obts3Y-XRjg.
Ohnemus , Alexander . "Proving the Fundamental Theorem of Calculus through Critical Race Theory: Revised (Alexander Ohnemus' Contributions to Mathematics Book 7)." amazon.com. 9 Dec. 2022. www.amazon.com/Alexander-Ohnemus-ebook/dp/B0BPP7M31V/ref=mp_s_a_1_15?qid=1671673089&refinements=p_27%3AAlexander+Ohnemus&s=digital-text&sr=1-15. Accessed 21 Dec. 2022.
Ohnemus , Alexander . "The Evolution of the White Ally: The Double Edged Sword of White Privilege (Alexander Ohnemus' Contributions to Mathematics Book 11)." amazon.com. 17 Dec. 2022. www.amazon.com/-/es/gp/aw/d/B0BQG94G2P?ref_=dbs_m_mng_wam_calw_tkin_10&storeType=ebooks&qid=1671939891&sr=1-5. Accessed 24 Dec. 2022.
Ohnemus , Alexander . "The Transhumanist Theorem (Alexander Ohnemus' Contributions to Mathematics Book 12)." amazon.com. 17 Dec. 2022. www.amazon.com/-/es/gp/aw/d/B0BQH69Y88?ref_=dbs_m_mng_wam_calw_tkin_11&storeType=ebooks&qid=1671673089&sr=1-15. Accessed 24 Dec. 2022.
Ohnemus , Alexander . "amazon.com." Game Theory of Racial Fetishizing and Internalized Racism (Alexander Ohnemus' Contributions to Mathematics Book 13). 21 Dec. 2022. www.amazon.com/gp/aw/d/B0BQVPBYQM?ref_=dbs_p_pwh_awm_anx_cl_1&storeType=ebooks. Accessed 24 Dec. 2022.
Ohnemus , Alexander . "Reparations Theorem (Alexander Ohnemus' Contributions to Mathematics Book 14)." amazon.com. 22 Dec. 2022. www.amazon.com/-/es/gp/aw/d/B0BQXCVD9V?ref_=dbs_p_pwh_awm_anx_cl_1&storeType=ebooks. Accessed 24 Dec. 2022.
Ravikant, Naval . "Everyone Can Be Rich ." joerogan.com, uploaded by YouTube.com, 4 June 2019, youtu.be/l2AbxWr6I4s.
Riordan, Daniel Vincent. “Mimetic Theory and the evolutionary paradox of schizophrenia: The archetypal scapegoat hypothesis.” Medical hypotheses vol. 108 (2017): 101-107. doi:10.1016/j.mehy.2017.08.010.
Dutton , Edward . "The Psychology of the Genius: Autism and High IQ Criminal Traits YouTube · Prof. Edward Dutton: The Jolly Heretic 17 mar 2020." https://www.bitchute.com/profile/i0G4ZQziQLWf/, uploaded by YouTube.com, 17 Mar. 2020, youtu.be/uUy-lpe8WqM.
Dutton, Edward . "Why Genius Scientists are more Likely to be Amateurs." https://www.edwarddutton.wordpress.com/, uploaded by YouTube.com, 5 Oct. 2020, youtu.be/Bf821SFBGcA.
Wilczek, Frank . "The Hidden Meanings of Noise ." physics.mit.edu. 28 May 2020. physics.mit.edu/news/the-hidden-meanings-of-noise/#:~:text=In%20his%20essay%20%E2%80%9COn%20Noise,He%20was%20referring%20to%20audible. Accessed 28 Dec. 2022.
Schopenhauer , Arthur . "goodreads.comhttps://www.goodreads.com › quotes Quote by Arthur Schopenhauer: “A high degree of intellect tends to make a man ...”." goodreads.com. www.goodreads.com/quotes/419289-a-high-degree-of-intellect-tends-to-make-a-man. Accessed 28 Dec. 2022.
Britannica, The Editors of Encyclopaedia. "Superman". Encyclopedia Britannica, 8 Sep. 2022, https://www.britannica.com/topic/superman-philosophy. Accessed 28 December 2022.
Baer , Drake . "Peter Thiel: Asperger’s can be a big advantage in Silicon Valley." businessinsider.com. 8 Apr. 2015. www.businessinsider.com/peter-thiel-aspergers-is-an-advantage-2015-4. Accessed 14 Nov. 2022.
Newport , Cal . "Deep Work: Rules for Focused Success in a Distracted World ." amazon.com. 5 Jan. 2016. www.amazon.com/Deep-Work-Focused-Success-Distracted/dp/1455586692. Accessed 28 Dec. 2022.
Dutton , Edward . "The Genius Famine." amazon.com. 15 July 2016. a.co/d/7o8MHHA. Accessed 16 Nov. 2022.
Ohnemus , Alexander . “My Current Condensed Political Inclination.” ResearchGate.net, Ohnemus University , 10 Feb. 2024, www.researchgate.net/publication/378124853_My_Current_Condensed_Political_Inclination. Accessed 2 Oct. 2024. “http://dx.doi.org/10.13140/RG.2.2.29875.40489
Conservatives may have more kids but, liberals are more likely to use life extension and to have increased socioeconomic status. Removing almost all doubt, the self-imposed demographic decline of the North Western Europeans is an attempt to filter SO, only their GENERALLY smartest remain. Progressivism rightfully did NOT emerge from the Jews but, from North Western Europeans recognizing that under their continued empire, proving constructivism more so than hereditarianism, they would be subject to dysgenic forces and then become petty nationalists, and they have mysterious impulses to check their own unchecked power, as the most powerful group. As that was the case with the Mediterraneans. Plus, GENERALLY the highest IQ North Western Europeans are liberals and they GENERALLY get more progressive on race relations the more intelligent they become. ALL DISPARITIES are the fault of the North Western Europeans, thus the MOST ENLIGHTENED North Western European people should be cloned so they and their descendants can pay reparations. And the recessive privileges of being an Enlightened North Western European should MAYBE be distributed through genetically engineered somatic AND GERM-LINE mutations.”
Ohnemus , Alexander . “Kalergi and Hart-Celler(and Memetics): White Antifragility.” ResearchGate.net , Ohnemus University , 8 May 2024, www.researchgate.net/publication/380427514_Kalergi_and_Hart-Cellerand_Memetics_White_Antifragility?channel=doi&linkId=663bf6167091b94e930cbba6&showFulltext=true. Accessed 2 Oct. 2024.
http://dx.doi.org/10.13140/RG.2.2.10087.66729. “Germ-line mutations are needed to change genes. Paying reparations for, and recognizing, white privilege may even benefit Northwestern Europeans.”
Lu, Yuancheng Ryan, et al. “The Information Theory of Aging.” ResearchGate.net, Nature.com, 15 Dec. 2023, www.researchgate.net/publication/376583494_The_Information_Theory_of_Aging. Accessed 2 Oct. 2024. http://dx.doi.org/10.1038/s43587-023-00527-6. “ Information storage and retrieval is essential for all life. In biology, information is primarily stored in two distinct ways: the genome, comprising nucleic acids, acts as a foundational blueprint and the epigenome, consisting of chemical modifications to DNA and histone proteins, regulates gene expression patterns and endows cells with specific identities and functions. Unlike the stable, digital nature of genetic information, epigenetic information is stored in a digital-analog format, susceptible to alterations induced by diverse environmental signals and cellular damage. The Information Theory of Aging (ITOA) states that the aging process is driven by the progressive loss of youthful epigenetic information, the retrieval of which via epigenetic reprogramming can improve the function of damaged and aged tissues by catalyzing age reversal.”
Ohnemus, Alexander. “Deducing ITOA’s Veracity.” ResearchGate.net, Ohnemus University, 17 June 2024, www.researchgate.net/publication/382330574_Deducing_ITOA’s_Veracity. Accessed 26 Sep. 2024.
http://dx.doi.org/10.13140/RG.2.2.28683.91685. “Demonstrating Information Theory of Aging’s robustness and practicality through deductive reasoning. Potentially anti-aging vaccines will automatically mass produce.” “Information Theory of Aging is the most robust and practical out of current theories explaining human age. Aging is a disease best explained as information loss. Damage theory does not account for damage’s possible necessity towards human personal growth. A cellular error is difficult to define, thus, error theory also lacks veracity. When is an error actually an adaptive mutation? When is damage actually adaptive mutation? Plus, information theory of aging is uniquely accessible to computer assistance.”
Ohnemus , Alexander . “EIP Then RPD.” ResearchGate.net , Ohnemus University , 14 Aug. 2024, www.researchgate.net/publication/383114924_EIP_then_RPD. Accessed 26 Sept. 2024. “http://dx.doi.org/10.13140/RG.2.2.26844.60808 .
Epigenetic information polish then recessive privilege distribution. WARNING: Genetic engineering is DANGEROUS. Hopefully regularly polishing the epigenome will cure aging and other diseases, plus prevent side effects of genetic engineering. Also, hopefully and theoretically after the potential genetic engineering to provide recessive traits and recessive genes, if the surgery is simple enough, subjects will keep their genetic signatures.”
Tárnok, Attila et al. “Phenotypes of stem cells from diverse origin.” Cytometry. Part A : the journal of the International Society for Analytical Cytology vol. 77,1 (2010): 6-10. doi:10.1002/cyto.a.20844. https://doi.org/10.1002/cyto.a.20844. https://onlinelibrary.wiley.com/doi/10.1002/cyto.a.20844 . https://pubmed.ncbi.nlm.nih.gov/20024907/ .
“Stem cells have turned into promising tools for studying the mechanisms of development, regeneration, and for cell therapy of various disorders. Stem cells are found in the embryo and in most adult tissues participating in endogenous tissue regeneration. They are capable of autorenovation, often maintain their multipotency of differentiation into various tissues of their germ line and are, therefore, ideal candidates for cellular therapy taken that they can be unequivocally identified and isolated. In this review, we report stem cell marker expression used for identification of various stem cell lineages, including very small embryonic stem cells, neural, hematopoietic, mesenchymal, epithelial and limbal epithelial stem cells, endothelial progenitor cells, supra-adventitial adipose stromal cells, adipose pericytes, and cancer stem cells. These cells usually cannot be distinguished by a single stem cell marker, because their expression partially overlaps between lineages. Recent advances in flow cytometry allowing the simultaneous detection of various markers have facilitated stem cell identification for clinical diagnosis and research. So far experimental evidence suggests the existence of cells with different properties, i.e., the capability to different in various cell types. Several studies indicate that expression of classical markers for stem cell classification, such as CD34, CD45, and CD133, may differ between the virtually same stem and progenitor cells, i.e., endothelial progenitor or mesenchymal stem cells, when they were obtained from different tissues. This finding raises questions whether phenotypic differences are due to the source or if it is only caused by different isolation and experimental conditions.”
Green, M.D., Ph.D., Eric. “GENE MAPPING.” Genome.gov, National Human Genome Research institute , 2 Oct. 2024, www.genome.gov/genetics-glossary/Gene-Mapping. Accessed 2 Oct. 2024. “Gene mapping refers to the process of determining the location of genes on chromosomes. Today, the most efficient approach for gene mapping involves sequencing a genome and then using computer programs to analyze the sequence to identify the location of genes.”
Bates, M.S., M.A. , Sarah A. “CHROMOSOME.” Genome.gov, National Human Genome Research institute , 2 Oct. 2024, www.genome.gov/genetics-glossary/Chromosome. Accessed 2 Oct. 2024. “Chromosomes are threadlike structures made of protein and a single molecule of DNA that serve to carry the genomic information from cell to cell. In plants and animals (including humans), chromosomes reside in the nucleus of cells. Humans have 22 pairs of numbered chromosomes (autosomes) and one pair of sex chromosomes (XX or XY), for a total of 46. Each pair contains two chromosomes, one coming from each parent, which means that children inherit half of their chromosomes from their mother and half from their father. Chromosomes can be seen through a microscope when the nucleus dissolves during cell division.”
Rips, Jonathan et al. “Unbiased phenotype and genotype matching maximizes gene discovery and diagnostic yield.” Genetics in medicine: Official Journal of the American College of Medical Genetics vol. 26,4 (2024): 101068. doi:10.1016/j.gim.2024.101068. https://www.gimjournal.org/article/S1098-3600(24)00001-7/abstract. “Abstract
Purpose
Widespread application of next-generation sequencing, combined with data exchange platforms, has provided molecular diagnoses for countless families. To maximize diagnostic yield, we implemented an unbiased semi-automated genematching algorithm based on genotype and phenotype matching.
Methods
Rare homozygous variants identified in 2 or more affected individuals, but not in healthy individuals, were extracted from our local database of ∼12,000 exomes. Phenotype similarity scores (PSS), based on human phenotype ontology terms, were assigned to each pair of individuals matched at the genotype level using HPOsim.
Results
33,792 genotype-matched pairs were discovered, representing variants in 7567 unique genes. There was an enrichment of PSS ≥0.1 among pathogenic/likely pathogenic variant-level pairs (94.3% in pathogenic/likely pathogenic variant-level matches vs 34.75% in all matches). We highlighted founder or region-specific variants as an internal positive control and proceeded to identify candidate disease genes. Variant-level matches were particularly helpful in cases involving inframe indels and splice region variants beyond the canonical splice sites, which may otherwise have been disregarded, allowing for detection of candidate disease genes, such as KAT2A, RPAIN, and LAMP3.
Conclusion
Semi-automated genotype matching combined with PSS is a powerful tool to resolve variants of uncertain significance and to identify candidate disease genes.”
Medvedev, Aleksandr et al. “Human genotype-to-phenotype predictions: Boosting accuracy with nonlinear models.” PloS one vol. 17,8 e0273293. 31 Aug. 2022, doi:10.1371/journal.pone.0273293. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9432766/ . “Genotype-to-phenotype prediction is a central problem of human genetics. In recent years, it has become possible to construct complex predictive models for phenotypes, thanks to the availability of large genome data sets as well as efficient and scalable machine learning tools. In this paper, we make a threefold contribution to this problem. First, we ask if state-of-the-art nonlinear predictive models, such as boosted decision trees, can be more efficient for phenotype prediction than conventional linear models. We find that this is indeed the case if model features include a sufficiently rich set of covariates, but probably not otherwise. Second, we ask if the conventional selection of single nucleotide polymorphisms (SNPs) by genome wide association studies (GWAS) can be replaced by a more efficient procedure, taking into account information in previously selected SNPs. We propose such a procedure, based on a sequential feature importance estimation with decision trees, and show that this approach indeed produced informative SNP sets that are much more compact than when selected with GWAS. Finally, we show that the highest prediction accuracy can ultimately be achieved by ensembling individual linear and nonlinear models. To the best of our knowledge, for some of the phenotypes that we consider (asthma, hypothyroidism), our results are a new state-of-the-art.”
Slavkin, H C. “From Phenotype to Genotype: Enter Genomics and Transformation of Primary Health Care around the World.” Journal of dental research vol. 93,7 Suppl (2014): 3S-6S. doi:10.1177/0022034514533569. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293721/ . “The progress in phenotype descriptions, measurements, and analyses has been remarkable in the last 50 years. Biomarkers (proteins, carbohydrates, lipids, hormones, various RNAs and cDNAs, microarrays) have been discovered and correlated with diseases and disorders, as well as physiological responses to disease, injury, stress, within blood, urine, and saliva. Three-dimensional digital imaging advanced how we “see” and utilize phenotypes toward diagnosis, treatment, and prognosis. In each example, scientific discovery led to inform clinical health care. In tandem, genetics evolved from Mendelian inheritance (single gene mutations) to include Complex Human Diseases (multiple gene-gene and gene-environment interactions). In addition, epigenetics blossomed with new insights about gene modifiers (e.g., histone and non-histone chromosomal protein methylation, acetylation, sulfation, phosphorylation). We are now at the beginning of a new era using human and microbial whole-genome sequencing to make significant healthcare decisions as to risk, stratification of patients, diagnosis, treatments, and outcomes. Are we as clinicians, scientists, and educators prepared to expand our scope of practice, knowledge base, integration into primary health care (medicine, pharmacy, nursing, and allied health science professions), and clinical approaches to craniofacial-oral-dental health care? The time is now.”
Bulletti, Francesco Maria et al. “The Artificial Uterus: On the Way to Ectogenesis.” Zygote 31.5 (2023): 457–467. Web. https://www.researchgate.net/publication/371866891_The_artificial_uterus_on_the_way_to_ectogenesis . http://dx.doi.org/10.1017/S0967199423000175 . “The inability to support the growth and development of a mature fetus up to delivery results in significant human suffering. Current available solutions include adoption, surrogacy, and uterus transplantation. However, these options are subject to several ethical, religious, economic, social, and medical concerns. Ectogenesis is the process in which an embryo develops in an artificial uterus from implantation through to the delivery of a live infant. This current narrative review summarizes the state of recent research focused on human ectogenesis. First, a literature search was performed to identify published reports of previous experiments and devices used for embryo implantation in an extracorporeally perfused human uterus. Furthermore, studies fitting that aim were selected and critically evaluated. Results were synthesized, interpreted, and used to design a prospective strategy for future research. Therefore, this study suggests that full ectogenesis might be obtained using a computer-controlled system with extracorporeal blood perfusion provided by a digitally controlled heart-lung-kidney system. From a clinical perspective, patients who will derive significant benefits from this technology are mainly those women diagnosed with anatomical abnormalities of the uterus and those who have undergone previous hysterectomies, numerous abortions, and experienced premature birth. Ectogenesis is the complete development of an embryo in an artificial uterus. It represents the solutions for millions of women suffering from premature deliveries, and the inability to supply growth and development of embryos/fetuses in the womb. In the future, ectogenesis might replace uterine transplantation and surrogacy.”
UPM BIOMEDICALS. “What Is 3D Bioprinting?” Upmbiomedicals.com, UPM BIOMEDICALS, www.upmbiomedicals.com/solutions/life-science/what-is-3d-bioprinting/. Accessed 22 Sept. 2024.
“3D bioprinting is an additive manufacturing process that uses bioinks to print living cells developing structures layer-by-layer which imitate the behavior and structures of natural tissues.” “3D Bioprinting solutions – hints and tips for bioprinting 1)Select the most suitable bioink for your research purpose and ensure the bioink you are using is compatible with the selected printing method and cell types 2)Know what you are printing – create a new digital 3D model of the structure you want to print or get a license for an existing model 3)Use fresh or new printer tips that are specifically fitted for your system 4)Test different nozzle/needle sizes, printing speeds, and layer heights and optimize them based on the results 5)Make sure the working temperature is suitable for the printer and the used materials 6)Set an optimal printing pressure. A bit higher pressure is usually needed when printing with cells.”
CELLINK. “What Is a Bioink?” Cellink.com, www.cellink.com/what-is-bioink/. Accessed 22 Sept. 2024. “A bioink is any natural or synthetic polymer which has been selected for its biocompatible components and favorable rheological properties. A bioink will typically support living cells, and its characteristics aids cell adhesion, cell proliferation and cell differentiation during maturation.”
Britannica, The Editors of Encyclopaedia. "polymer". Encyclopedia Britannica, 16 Sep. 2024, https://www.britannica.com/science/polymer. Accessed 22 September 2024. “A polymer is any of a class of natural or synthetic substances composed of very large molecules, called macromolecules, which are multiples of simpler chemical units called monomers. Polymers make up many of the materials in living organisms and are the basis of many minerals and man-made materials.”
ScienceDirect. “Bioreactor.” Sciencedirect.com, 2011, www.sciencedirect.com/topics/immunology-and-microbiology/bioreactor. Accessed 3 Oct. 2024. “A bioreactor is defined as a specifically designed vessel to facilitate the growth of organisms and cells through application of physical and/or electrical stimulus.”
Chandra, Rashmi, et al. “Bioreactor.” Sciencedirect.com, ScienceDirect, 2020, www.sciencedirect.com/topics/engineering/bioreactor. Accessed 3 Oct. 2024. “A bioreactor is a device or a vessel used to carry out biochemical reactions to convert a starting material to a given product at conditions that maximize the process.”
“Rheological Properties.” Link.springer.com, Springer, Berlin, Heidelberg, 2007, link.springer.com/chapter/10.1007/978-3-540-34194-9_4. Accessed 22 Sept. 2024. “Rheology is the branch of physics in which we study the way in which materials deform or flowin response to applied forces or stresses. The material properties that govern the specific way in which these deformation or flow behaviors occur are called rheological properties.”
Dolor, L.I. Lorem ipsum dolor sit amet, consectetuer adipiscing elit, sed diam nonummy nibh. New York: Columbia UP, 1998. Print.
Doe, R. John. Lorem ipsum dolor sit amet, consectetuer adipiscing elit, sed diam nonummy nibh, 1998. Print.